Therapy Focus:
Understanding CASAD Applications
The Problem
Severe diarrhea and other GI inflammatory conditions have many causes. From cancer therapy to HIV/AIDS treatment, infectious diseases to radiation injury and toxic pharmaceuticals, side effects can be debilitating. They can create a cytokine storm within the patient’s system, endanger primary therapy success, reduce quality of life and be potentially life threatening.
For example, diarrhea impedes the body’s ability to function as it prevents the retention of necessary nutrients, electrolytes and fluids. Oral lesions can be painful, resulting in the reduction of oral intake. These and other issues can interfere with therapy and overall patient health and recovery.
In the case of severe diarrhea, there are many products on the market that attempt to treat it, but there are none that prevent it. There is not one reliable, widely accepted treatment for severe diarrhea conditions. At Salient, we hope to change that as we explore the prevention and/or treatment of diarrhea and other GI inflammatory conditions associated with disease therapy, chronic conditions and infectious disease.
In some situations, such as colitis, steroids and other products with significant side effects are used to help manage the patient’s condition. Salient is exploring non-steroid methods for preventing and managing diarrhea flare-ups for patients living with inflammatory bowel diseases.
The Salient Solution
The concept behind Salient’s solution is that removing the toxin(s) or other inflammatory agent(s) from the patient’s GI tract and neutralizing the cytokine storm will result in improved patient outcomes. Chemotherapy-induced diarrhea is a good example of this concept in action. By removing unwanted drugs, drug metabolites and other inflammatory agents, such as TNF α, the incidence of diarrhea may be significantly reduced. Salient can accomplish this by using a composition of a unique, all-natural mineral, which attracts and selectively binds certain toxins and inflammatory proteins. This composition keeps the inflammatory substance from irritating the GI tract.
